The February edition of the British Journal of Psychiatry has a thought-provoking editorial by psychiatrist Jim van Os, arguing that we should reject the diagnosis of schizophrenia owing to its lack of validity and replace it with a concept of a 'salience dysregulation...

According to theaberrant salience account of schizophrenia, the positive symptoms of the condition - the hallucinations and delusions - come about because patients see meaning where there is none. The neurotransmitter dopamine, associated with learning and...

Regular readers of this blog will know that I subscribe to the incentive salience theory of doapmaine propounded by Berridge et al. As per this theory dopamine mediates the salience of an internal/ external stimulus and endows and activates the motivational...

The February edition of the British Journal of Psychiatry has a thought-provoking editorial by psychiatrist Jim van Os, arguing that we should reject the diagnosis of schizophrenia owing to its lack of validity and replace it with a concept of a 'salience dysregulation...